Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling

Taste receptors exist in several organs from tongue to colon and have diverse functions dependent on specific cell type. In enteroendocrine L-cells, stimulation of taste receptor signaling induces incretin hormones. Among incretin hormones, glucagon-like peptide-1 (GLP-1) induces insulinotropic acti...

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Vydáno v:Front Pharmacol
Hlavní autoři: Kim, Kang-Hoon, Lee, In-Seung, Park, Ji Young, Kim, Yumi, An, Eun-Jin, Jang, Hyeung-Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161541/
https://ncbi.nlm.nih.gov/pubmed/30298009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01071
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