Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors,...

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Bibliografiske detaljer
Main Authors: Jang, Hyeung-Jin, Kokrashvili, Zaza, Theodorakis, Michael J., Carlson, Olga D., Kim, Byung-Joon, Zhou, Jie, Kim, Hyeon Ho, Xu, Xiangru, Chan, Sic L., Juhaszova, Magdalena, Bernier, Michel, Mosinger, Bedrich, Margolskee, Robert F., Egan, Josephine M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986614/
https://ncbi.nlm.nih.gov/pubmed/17724330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706890104
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