Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis

VEGF binding to VEGFR2 leads to VEGFR2 endocytosis and downstream signaling activation to promote angiogenesis. Methods: Using genetic strategies, we tested the requirement of α subunits of heterotrimeric G proteins (Gαi1/3) in the process. Results: Gαi1/3 are located in the VEGFR2 endocytosis compl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Sun, Jian, Huang, Wei, Yang, Shuo-fei, Zhang, Xiao-pei, Yu, Qing, Zhang, Zhi-qing, Yao, Jin, Li, Ke-ran, Jiang, Qin, Cao, Cong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160771/
https://ncbi.nlm.nih.gov/pubmed/30279732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.26203
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge