Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

IL-4 induces Akt activation in macrophages, required for full M2 (alternative) polarization. We examined the roles of Gαi1 and Gαi3 in M2 polarization using multiple genetic methods. Methods and Results: In MEFs and primary murine BMDMs, Gαi1/3 shRNA, knockout or dominant negative mutations attenuat...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Bai, Jin-yu, Li, Ya, Xue, Guan-hua, Li, Ke-ran, Zheng, Yu-Fan, Zhang, Zhi-qing, Jiang, Qin, Liu, Yuan-yuan, Zhou, Xiao-zhong, Cao, Cong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978294/
https://ncbi.nlm.nih.gov/pubmed/33754034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.56383
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