Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

BACKGROUND: Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known. METHODS: We used in vivo confocal microscopy to compare the effects of inflammation in experimenta...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Sajic, Marija, Ida, Keila Kazue, Canning, Ryan, Gregson, Norman A., Duchen, Michael R, Smith, Kenneth J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160719/
https://ncbi.nlm.nih.gov/pubmed/29486771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1094-8
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