Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

BACKGROUND: Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known. METHODS: We used in vivo confocal microscopy to compare the effects of inflammation in experimenta...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Sajic, Marija, Ida, Keila Kazue, Canning, Ryan, Gregson, Norman A., Duchen, Michael R, Smith, Kenneth J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160719/
https://ncbi.nlm.nih.gov/pubmed/29486771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1094-8
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