RNA modification landscape of the human mitochondrial tRNA(Lys) regulates protein synthesis

Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Richter, Uwe, Evans, Molly E., Clark, Wesley C., Marttinen, Paula, Shoubridge, Eric A., Suomalainen, Anu, Wredenberg, Anna, Wedell, Anna, Pan, Tao, Battersby, Brendan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160436/
https://ncbi.nlm.nih.gov/pubmed/30262910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06471-z
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