Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology

Induction of TLR2 activation depends on its association with the adapter protein MyD88. We have found that TLR2 and MyD88 levels are elevated in the hippocampus and cortex of patients with Alzheimer’s disease (AD) and in a 5XFAD mouse model of AD. Since there is no specific inhibitor of TLR2, to tar...

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Publicado en:J Clin Invest
Autores principales: Rangasamy, Suresh B., Jana, Malabendu, Roy, Avik, Corbett, Grant T., Kundu, Madhuchhanda, Chandra, Sujyoti, Mondal, Susanta, Dasarathi, Sridevi, Mufson, Elliott J., Mishra, Rama K., Luan, Chi-Hao, Bennett, David A., Pahan, Kalipada
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159992/
https://ncbi.nlm.nih.gov/pubmed/29990310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96209
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