CD122 signaling in CD8(+) memory T cells drives costimulation-independent rejection

Interrupting T cell costimulatory signals as a strategy to control undesired immune responses, such as occur in autoimmunity or transplantation, has the potential to alleviate many of the unwanted side effects associated with current immunosuppressive therapies. Belatacept, a high-affinity version o...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Mathews, David V., Dong, Ying, Higginbotham, Laura B., Kim, Steven C., Breeden, Cynthia P., Stobert, Elizabeth A., Jenkins, Joseph, Tso, J. Yun, Larsen, Christian P., Adams, Andrew B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159972/
https://ncbi.nlm.nih.gov/pubmed/30222140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95914
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