Mutant NPM1 maintains the leukemic state through HOX expression

NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia (AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the mutant protein (NPM1c), however it is unknown whether NPM1c is required to maintain the leukemic state. Here, we show that...

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Publié dans:Cancer Cell
Auteurs principaux: Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159911/
https://ncbi.nlm.nih.gov/pubmed/30205049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.08.005
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