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High Concentration Formulations of Recombinant Human Interleukin-1 Receptor Antagonist: I. Physical Characterization
At relatively high protein concentrations (i.e., up to 100 mg/mL), recombinant human interleukin-1 receptor antagonist (rhIL-1ra) was found to exist in a monomer–dimer equilibrium controlled by solution ionic strength. Sedimentation equilibrium at 25°C was used to measure the increase in the dimer d...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6159223/ https://ncbi.nlm.nih.gov/pubmed/17973297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21199 |
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