High Concentration Formulations of Recombinant Human Interleukin-1 Receptor Antagonist: I. Physical Characterization

At relatively high protein concentrations (i.e., up to 100 mg/mL), recombinant human interleukin-1 receptor antagonist (rhIL-1ra) was found to exist in a monomer–dimer equilibrium controlled by solution ionic strength. Sedimentation equilibrium at 25°C was used to measure the increase in the dimer d...

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Publicado no:J Pharm Sci
Main Authors: ALFORD, JOHN R., KWOK, STANLEY C., ROBERTS, JENNIFER N., WUTTKE, DEBORAH S., KENDRICK, BRENT S., CARPENTER, JOHN F., RANDOLPH, THEODORE W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159223/
https://ncbi.nlm.nih.gov/pubmed/17973297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21199
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