Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma

BACKGROUND: Both cis- and trans-cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method to simultaneously determine both isomers for pharmacokinetic and bioequivalence studies. METHODS: An LC-MS/MS method, using stable i...

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Bibliografiske detaljer
Udgivet i:Int J Anal Chem
Main Authors: He, Guodong, Mai, Liping, Wang, Xipei
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158942/
https://ncbi.nlm.nih.gov/pubmed/30302091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/6959761
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