Nucleosome conformational variability in solution and in interphase nuclei evidenced by cryo-electron microscopy of vitreous sections

In Eukaryotes, DNA is wound around the histone octamer forming the basic chromatin unit, the nucleosome. Atomic structures have been obtained from crystallography and single particle cryo-electron microscopy (cryoEM) of identical engineered particles. But native nucleosomes are dynamical entities wi...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Eltsov, Mikhail, Grewe, Diana, Lemercier, Nicolas, Frangakis, Achilleas, Livolant, Françoise, Leforestier, Amélie
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158616/
https://ncbi.nlm.nih.gov/pubmed/30053160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky670
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