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Nucleosome conformational variability in solution and in interphase nuclei evidenced by cryo-electron microscopy of vitreous sections

In Eukaryotes, DNA is wound around the histone octamer forming the basic chromatin unit, the nucleosome. Atomic structures have been obtained from crystallography and single particle cryo-electron microscopy (cryoEM) of identical engineered particles. But native nucleosomes are dynamical entities wi...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Eltsov, Mikhail, Grewe, Diana, Lemercier, Nicolas, Frangakis, Achilleas, Livolant, Françoise, Leforestier, Amélie
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158616/
https://ncbi.nlm.nih.gov/pubmed/30053160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky670
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