Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency

Sin3a is a core component of histone-deacetylation-activity-associated transcriptional repressor complex, playing important roles in early embryo development. Here, we reported that down-regulation of Sin3a led to the loss of embryonic stem cell (ESC) self-renewal and skewed differentiation into mes...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Zhu, Fugui, Zhu, Qianshu, Ye, Dan, Zhang, Qingquan, Yang, Yiwei, Guo, Xudong, Liu, Zhenping, Jiapaer, Zeyidan, Wan, Xiaoping, Wang, Guiying, Chen, Wen, Zhu, Songcheng, Jiang, Cizhong, Shi, Weiyang, Kang, Jiuhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158608/
https://ncbi.nlm.nih.gov/pubmed/29733394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky347
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky