An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically promoted the maturation of iPS cells. Further studies sho...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wei, Tingyi, Chen, Wen, Wang, Xiukun, Zhang, Man, Chen, Jiayu, Zhu, Songcheng, Chen, Long, Yang, Dandan, Wang, Guiying, Jia, Wenwen, Yu, Yangyang, Duan, Tao, Wu, Minjuan, Liu, Houqi, Gao, Shaorong, Kang, Jiuhong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477660/
https://ncbi.nlm.nih.gov/pubmed/25934799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv430
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