Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis

Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable mutations, underscoring the necessity to exploit epigenetic vulnerabilities for therapeutics. In HCC, EZH2-mediated H3K27me3 represents a major oncogenic chromatin modification, but how it modulates the therapeutic...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lee, Ying-Ying, Mok, Myth TS, Kang, Wei, Yang, Weiqin, Tang, Wenshu, Wu, Feng, Xu, Liangliang, Yan, Mingfei, Yu, Zhuo, Lee, Sau-Dan, Tong, Joanna H M, Cheung, Yue-Sun, Lai, Paul B S, Yu, Dae-Yeul, Wang, Qianben, Wong, Grace L H, Chan, Andrew M, Yip, Kevin Y, To, Ka-Fai, Cheng, Alfred S L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158508/
https://ncbi.nlm.nih.gov/pubmed/29992318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky589
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