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HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells

Tanshinone IIA (TIIA) is a diterpenoid naphthoquinone isolated from the herb Salvia miltiorrhiza with antitumor effects manifested at multiple levels that are mechanistically obscure. In our previous studies, we illustrated that TIIA treatment triggered apoptosis in human osteosarcoma 143B cells bot...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Yen, Jia-Hau, Huang, Sheng-Teng, Huang, Hung-Sen, Fong, Yi-Chin, Wu, Yi-Ying, Chiang, Jen-Huai, Su, Yuan-Chih
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158215/
https://ncbi.nlm.nih.gov/pubmed/30258193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1016-9
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