Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Vojinovic, Dina, Adams, Hieab H., Jian, Xueqiu, Yang, Qiong, Smith, Albert Vernon, Bis, Joshua C., Teumer, Alexander, Scholz, Markus, Armstrong, Nicola J., Hofer, Edith, Saba, Yasaman, Luciano, Michelle, Bernard, Manon, Trompet, Stella, Yang, Jingyun, Gillespie, Nathan A., van der Lee, Sven J., Neumann, Alexander, Ahmad, Shahzad, Andreassen, Ole A., Ames, David, Amin, Najaf, Arfanakis, Konstantinos, Bastin, Mark E., Becker, Diane M., Beiser, Alexa S., Beyer, Frauke, Brodaty, Henry, Bryan, R. Nick, Bülow, Robin, Dale, Anders M., De Jager, Philip L., Deary, Ian J., DeCarli, Charles, Fleischman, Debra A., Gottesman, Rebecca F., van der Grond, Jeroen, Gudnason, Vilmundur, Harris, Tamara B., Homuth, Georg, Knopman, David S., Kwok, John B., Lewis, Cora E., Li, Shuo, Loeffler, Markus, Lopez, Oscar L., Maillard, Pauline, El Marroun, Hanan, Mather, Karen A., Mosley, Thomas H., Muetzel, Ryan L., Nauck, Matthias, Nyquist, Paul A., Panizzon, Matthew S., Pausova, Zdenka, Psaty, Bruce M., Rice, Ken, Rotter, Jerome I., Royle, Natalie, Satizabal, Claudia L., Schmidt, Reinhold, Schofield, Peter R., Schreiner, Pamela J., Sidney, Stephen, Stott, David J., Thalamuthu, Anbupalam, Uitterlinden, Andre G., Valdés Hernández, Maria C., Vernooij, Meike W., Wen, Wei, White, Tonya, Witte, A. Veronica, Wittfeld, Katharina, Wright, Margaret J., Yanek, Lisa R., Tiemeier, Henning, Kremen, William S., Bennett, David A., Jukema, J. Wouter, Paus, Tomas, Wardlaw, Joanna M., Schmidt, Helena, Sachdev, Perminder S., Villringer, Arno, Grabe, Hans Jörgen, Longstreth, W T, van Duijn, Cornelia M., Launer, Lenore J., Seshadri, Sudha, Ikram, M Arfan, Fornage, Myriam
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Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158214/
https://ncbi.nlm.nih.gov/pubmed/30258056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06234-w
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