Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis...

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Publicado en:Nat Commun
Main Authors: Vojinovic, Dina, Adams, Hieab H., Jian, Xueqiu, Yang, Qiong, Smith, Albert Vernon, Bis, Joshua C., Teumer, Alexander, Scholz, Markus, Armstrong, Nicola J., Hofer, Edith, Saba, Yasaman, Luciano, Michelle, Bernard, Manon, Trompet, Stella, Yang, Jingyun, Gillespie, Nathan A., van der Lee, Sven J., Neumann, Alexander, Ahmad, Shahzad, Andreassen, Ole A., Ames, David, Amin, Najaf, Arfanakis, Konstantinos, Bastin, Mark E., Becker, Diane M., Beiser, Alexa S., Beyer, Frauke, Brodaty, Henry, Bryan, R. Nick, Bülow, Robin, Dale, Anders M., De Jager, Philip L., Deary, Ian J., DeCarli, Charles, Fleischman, Debra A., Gottesman, Rebecca F., van der Grond, Jeroen, Gudnason, Vilmundur, Harris, Tamara B., Homuth, Georg, Knopman, David S., Kwok, John B., Lewis, Cora E., Li, Shuo, Loeffler, Markus, Lopez, Oscar L., Maillard, Pauline, El Marroun, Hanan, Mather, Karen A., Mosley, Thomas H., Muetzel, Ryan L., Nauck, Matthias, Nyquist, Paul A., Panizzon, Matthew S., Pausova, Zdenka, Psaty, Bruce M., Rice, Ken, Rotter, Jerome I., Royle, Natalie, Satizabal, Claudia L., Schmidt, Reinhold, Schofield, Peter R., Schreiner, Pamela J., Sidney, Stephen, Stott, David J., Thalamuthu, Anbupalam, Uitterlinden, Andre G., Valdés Hernández, Maria C., Vernooij, Meike W., Wen, Wei, White, Tonya, Witte, A. Veronica, Wittfeld, Katharina, Wright, Margaret J., Yanek, Lisa R., Tiemeier, Henning, Kremen, William S., Bennett, David A., Jukema, J. Wouter, Paus, Tomas, Wardlaw, Joanna M., Schmidt, Helena, Sachdev, Perminder S., Villringer, Arno, Grabe, Hans Jörgen, Longstreth, W T, van Duijn, Cornelia M., Launer, Lenore J., Seshadri, Sudha, Ikram, M Arfan, Fornage, Myriam
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158214/
https://ncbi.nlm.nih.gov/pubmed/30258056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06234-w
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