A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

Attachment of ubiquitin to lysine 119 of Histone 2A (H2AK119Ub) is an epigenetic mark characteristic of repressed developmental genes, which is removed by the Polycomb Repressive-Deubiquitinase (PR-DUB) complex. Here we report the crystal structure of the Drosophila PR-DUB, revealing that the deubiq...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Foglizzo, Martina, Middleton, Adam J., Burgess, Abigail E., Crowther, Jennifer M., Dobson, Renwick C. J., Murphy, James M., Day, Catherine L., Mace, Peter D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158172/
https://ncbi.nlm.nih.gov/pubmed/30258054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06186-1
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