Model‐Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans

Bile acids released postprandially can modify the rate and extent of lipophilic compounds’ absorption. This study aimed to predict the enterohepatic circulation (EHC) of total bile acids (TBAs) in response to caloric intake from their spillover in plasma. A model for TBA EHC was combined with a prev...

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Библиографические подробности
Опубликовано в: :CPT Pharmacometrics Syst Pharmacol
Главные авторы: Guiastrennec, Benjamin, Sonne, David P., Bergstrand, Martin, Vilsbøll, Tina, Knop, Filip K., Karlsson, Mats O.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157686/
https://ncbi.nlm.nih.gov/pubmed/30070437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12325
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