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Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction
Somatic mutations on glycine 34 of histone H3 (H3G34) cause pediatric cancers, but the underlying oncogenic mechanism remains unknown. We demonstrate that substituting H3G34 with arginine, valine, or aspartate (H3G34R/V/D), which converts the non-side chain glycine to a large side chain-containing r...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156674/ https://ncbi.nlm.nih.gov/pubmed/30181289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806355115 |
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