Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders

In red blood cell (RBC) diseases, the spleen contributes to anemia by clearing the damaged RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing other pathogenic effects. We have analyzed RBCs in hereditary spherocytosis (HS) and hereditary elliptocytosis (HE),...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Li, He, Lu, Lu, Li, Xuejin, Buffet, Pierre A., Dao, Ming, Karniadakis, George E., Suresh, Subra
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156670/
https://ncbi.nlm.nih.gov/pubmed/30190436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806501115
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