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Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

Calcium (Ca(2+)) homeostasis is essential for neuronal function and survival. Altered Ca(2+) homeostasis has been consistently observed in neurological diseases. How Ca(2+) homeostasis is achieved in various cellular compartments of disease-relevant cell types is not well understood. Here we show in...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Lee, Kyu-Sun, Huh, Sungun, Lee, Seongsoo, Wu, Zhihao, Kim, Ae-Kyeong, Kang, Ha-Young, Lu, Bingwei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156612/
https://ncbi.nlm.nih.gov/pubmed/30185553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721136115
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