Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation

Ehrlichia chaffeensis, an obligatory intracellular bacterium, infects monocytes/macrophages by sequestering a regulator of endosomal traffic, the small GTPase RAB5, on its membrane-bound inclusions to avoid routing to host-cell phagolysosomes. How RAB5 is sequestered on ehrlichial inclusions is poor...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yan, Qi, Lin, Mingqun, Huang, Weiyan, Teymournejad, Omid, Johnson, Jennifer M., Hays, Franklin A., Liang, Zhimin, Li, Guangpu, Rikihisa, Yasuko
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156607/
https://ncbi.nlm.nih.gov/pubmed/30181274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806904115
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