Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development

In this study, we determined if BRCA1 partners involved in DNA double-strand break (DSB) and mismatch repair (MMR) may contribute to breast and ovarian cancer development. Taking advantage the functional conservation of DNA repair pathways between yeast and human, we expressed several BRCA1 missense...

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Publicado en:Front Genet
Autores principales: Maresca, Luisa, Lodovichi, Samuele, Lorenzoni, Alessandra, Cervelli, Tiziana, Monaco, Rossella, Spugnesi, Laura, Tancredi, Mariella, Falaschi, Elisabetta, Zavaglia, Katia, Landucci, Elisabetta, Roncella, Manuela, Congregati, Caterina, Gadducci, Angiolo, Naccarato, Antonio Giuseppe, Caligo, Maria Adelaide, Galli, Alvaro
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156519/
https://ncbi.nlm.nih.gov/pubmed/30283497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00397
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