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Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified by ATF6, undergo intramembrane-pr...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156501/ https://ncbi.nlm.nih.gov/pubmed/30254311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32705-7 |
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