Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels

Calmodulin (CaM) serves as a pervasive regulatory subunit of Ca(V)1, Ca(V)2, and Na(V)1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca(2+)-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters functional adaptability, a...

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Bibliographic Details
Published in:eLife
Main Authors: Niu, Jacqueline, Dick, Ivy E, Yang, Wanjun, Bamgboye, Moradeke A, Yue, David T, Tomaselli, Gordon, Inoue, Takanari, Ben-Johny, Manu
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156082/
https://ncbi.nlm.nih.gov/pubmed/30198845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35222
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