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Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels
Calmodulin (CaM) serves as a pervasive regulatory subunit of Ca(V)1, Ca(V)2, and Na(V)1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca(2+)-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters functional adaptability, a...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156082/ https://ncbi.nlm.nih.gov/pubmed/30198845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35222 |
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