Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Therapies to prevent maternal Zika virus (ZIKV) infection and its subsequent fetal developmental complications are urgently required. We isolated three potent ZIKV-neutralizing monoclonal antibodies (nmAbs) from the plasmablasts of a ZIKV-infected patient—SMZAb1, SMZAb2, and SMZAb5—directed against...

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Publicat a:Sci Transl Med
Autors principals: Magnani, Diogo M., Rogers, Thomas, Beutler, Nathan, Ricciardi, Michael J., Bailey, Varian K., Gonzalez-Nieto, Lucas, Briney, Bryan, Sok, Devin, Le, Khoa, Strubel, Alexander, Gutman, Martin J., Pedreño-Lopez, Núria, Grubaugh, Nathan D., Silveira, Cassia G. T., Maxwell, Helen S., Domingues, Aline, Martins, Mauricio A., Lee, David E., Okwuazi, Erica E., Jean, Sherrie, Strobert, Elizabeth A., Chahroudi, Ann, Silvestri, Guido, Vanderford, Thomas H., Kallas, Esper G., Desrosiers, Ronald C., Bonaldo, Myrna C., Whitehead, Stephen S., Burton, Dennis R., Watkins, David I.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155977/
https://ncbi.nlm.nih.gov/pubmed/28978754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan8184
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