Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as start...

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Publicado en:Molecules
Autores principales: Urgin, Karène, Jida, Mouhamad, Ehrhardt, Katharina, Müller, Tobias, Lanzer, Michael, Maes, Louis, Elhabiri, Mourad, Davioud-Charvet, Elisabeth
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155649/
https://ncbi.nlm.nih.gov/pubmed/28106855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22010161
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