The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

Previously, we presented the chemical design of a promising series of antimalarial agents, 3-[substituted-benzyl]-menadiones, with potent in vitro and in vivo activities. Ongoing studies on the mode of action of antimalarial 3-[substituted-benzyl]-menadiones revealed that these agents disturb the re...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ehrhardt, Katharina, Deregnaucourt, Christiane, Goetz, Alice-Anne, Tzanova, Tzvetomira, Gallo, Valentina, Arese, Paolo, Pradines, Bruno, Adjalley, Sophie H., Bagrel, Denyse, Blandin, Stephanie, Lanzer, Michael, Davioud-Charvet, Elisabeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997830/
https://ncbi.nlm.nih.gov/pubmed/27297478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02975-15
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