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Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability

Genomic instability is a major driver of intra-tumor heterogeneity. However, unstable genomes often exhibit different molecular and clinical phenotypes, which are associated with distinct mutational processes. Here, we algorithmically inferred the clonal phylogenies of ~6,000 human tumors from 32 tu...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Raynaud, Franck, Mina, Marco, Tavernari, Daniele, Ciriello, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155543/
https://ncbi.nlm.nih.gov/pubmed/30212491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007669
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