AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

AM-2201 is a synthetic cannabinoid that acts as a potent agonist at cannabinoid receptors and its abuse has increased. However, there are no reports of the inhibitory effect of AM-2201 on human cytochrome P450 (CYP) or uridine 5′-diphospho-glucuronosyltransferase (UGT) enzymes. We evaluated the inhi...

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Udgivet i:Molecules
Main Authors: Kim, Ju-Hyun, Kwon, Soon-Sang, Kong, Tae Yeon, Cheong, Jae Chul, Kim, Hee Seung, In, Moon Kyo, Lee, Hye Suk
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155437/
https://ncbi.nlm.nih.gov/pubmed/28287454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22030443
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