Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes

Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody–drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5′-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes and its effects on the mRNA expression of cytochrome P450s (...

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Vydáno v:Pharmaceutics
Hlavní autoři: Choi, Won-Gu, Park, Ria, Kim, Dong Kyun, Shin, Yongho, Cho, Yong-Yeon, Lee, Hye Suk
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150891/
https://ncbi.nlm.nih.gov/pubmed/32131538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12030220
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