2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β(3)-Adrenergic Activity

The β(3) adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high affinity ligands have been made. Currently, Mirabegron is the only available dr...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Apablaza, Gastón, Montoya, Luisa, Morales-Verdejo, Cesar, Mellado, Marco, Cuellar, Mauricio, Lagos, Carlos F., Soto-Delgado, Jorge, Chung, Hery, Pessoa-Mahana, Carlos David, Mella, Jaime
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155312/
https://ncbi.nlm.nih.gov/pubmed/28273884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22030404
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