Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Tuberous Sclerosis Complex (TSC), a rare genetic disorder with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivation, is characterized by multi-organ hamartomatous benign tumors including brain, skin, kidney, and lung (Lymphangioleiomyomatosis). mTORC1 hyperactivation drives metabolic r...

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Published in:Sci Rep
Main Authors: Filippakis, Harilaos, Belaid, Amine, Siroky, Brian, Wu, Constance, Alesi, Nicola, Hougard, Thomas, Nijmeh, Julie, Lam, Hilaire C., Henske, Elizabeth P.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155086/
https://ncbi.nlm.nih.gov/pubmed/30242175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32256-x
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