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Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored in the pancreas, while insulin-like growth factor-1 (IGF-1) is maintained in blood...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Roed, Nikolaj Kulahin, Viola, Cristina M., Kristensen, Ole, Schluckebier, Gerd, Norrman, Mathias, Sajid, Waseem, Wade, John D., Andersen, Asser Sloth, Kristensen, Claus, Ganderton, Timothy R., Turkenburg, Johan P., De Meyts, Pierre, Brzozowski, Andrzej M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155051/
https://ncbi.nlm.nih.gov/pubmed/30242155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06192-3
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