Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation

We report the crystal structure of two variants of Drosophila melanogaster insulin-like peptide 5 (DILP5) at a resolution of 1.85 Å. DILP5 shares the basic fold of the insulin peptide family (T conformation) but with a disordered B-chain C terminus. DILP5 dimerizes in the crystal and in solution. Th...

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Main Authors: Sajid, Waseem, Kulahin, Nikolaj, Schluckebier, Gerd, Ribel, Ulla, Henderson, Hope Rosalind, Tatar, Marc, Hansen, Bo Falck, Svendsen, Angela Manegold, Kiselyov, Vladislav V., Nørgaard, Per, Wahlund, Per-Olof, Brandt, Jakob, Kohanski, Ronald A., Andersen, Asser Sloth, De Meyts, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013025/
https://ncbi.nlm.nih.gov/pubmed/20974844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156018
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