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Protein kinase Cι: A versatile oncogene in the lung

We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.(1) Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-dr...

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Vydáno v:Mol Cell Oncol
Hlavní autoři: Fields, Alan P., Ali, Syed A., Justilien, Verline, Murray, Nicole R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154840/
https://ncbi.nlm.nih.gov/pubmed/30263934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1190886
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