PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies

OBJECTIVE: The first aim of this study was to develop a nanocarrier that could transport the peroxisome proliferator-activated receptor agonist, pioglitazone (PGZ) across brain endothelium and examine the mechanism of nanoparticle transcytosis. The second aim was to determine whether these nanocarri...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Silva-Abreu, Marcelle, Calpena, Ana Cristina, Andrés-Benito, Pol, Aso, Ester, Romero, Ignacio A, Roig-Carles, David, Gromnicova, Radka, Espina, Marta, Ferrer, Isidre, García, María Luisa, Male, David
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154713/
https://ncbi.nlm.nih.gov/pubmed/30271148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S171490
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