Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain

Background: Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3). Several studies point to imp...

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Publicado en:Thyroid
Autores principales: Bárez-López, Soledad, Hartley, Meredith D., Grijota-Martínez, Carmen, Scanlan, Thomas S., Guadaño-Ferraz, Ana
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc., publishers 2018
Materias:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154442/
https://ncbi.nlm.nih.gov/pubmed/29845892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2018.0008
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