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Assessing Scaffold Diversity of Kinase Inhibitors Using Alternative Scaffold Concepts and Estimating the Scaffold Hopping Potential for Different Kinases

Publicly available kinase inhibitors provide a large source of information for structure–activity relationship analysis and kinase drug design. In this study, publicly available inhibitors of the human kinome were collected and analog series formed by kinase inhibitors systematically identified. The...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Dimova, Dilyana, Bajorath, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154288/
https://ncbi.nlm.nih.gov/pubmed/28467353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22050730
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