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Assessing Scaffold Diversity of Kinase Inhibitors Using Alternative Scaffold Concepts and Estimating the Scaffold Hopping Potential for Different Kinases

Publicly available kinase inhibitors provide a large source of information for structure–activity relationship analysis and kinase drug design. In this study, publicly available inhibitors of the human kinome were collected and analog series formed by kinase inhibitors systematically identified. The...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Dimova, Dilyana, Bajorath, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154288/
https://ncbi.nlm.nih.gov/pubmed/28467353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22050730
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