Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome

The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; TCDD), which includes thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. Although the mechanisms of dioxin toxicity remain unknown, AHR signaling in he...

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Udgivet i:Toxicol Sci
Main Authors: Hutin, David, Tamblyn, Laura, Gomez, Alvin, Grimaldi, Giulia, Soedling, Helen, Cho, Tiffany, Ahmed, Shaimaa, Lucas, Christin, Kanduri, Chakravarthi, Grant, Denis M, Matthews, Jason
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
The Negative AHR Receptor Activator Tiparp and Dioxin Wasting
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154274/
https://ncbi.nlm.nih.gov/pubmed/29873790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy136
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