Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these...

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Опубликовано в: :Front Chem
Главные авторы: Rao, Geeta, Nkepang, Gregory, Xu, Jian, Yari, Hooman, Houson, Hailey, Teng, Chengwen, Awasthi, Vibhudutta
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153970/
https://ncbi.nlm.nih.gov/pubmed/30280096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00392
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