Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Rao, Geeta, Nkepang, Gregory, Xu, Jian, Yari, Hooman, Houson, Hailey, Teng, Chengwen, Awasthi, Vibhudutta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153970/
https://ncbi.nlm.nih.gov/pubmed/30280096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00392
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