Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these...

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Bibliographic Details
Published in:Front Chem
Main Authors: Rao, Geeta, Nkepang, Gregory, Xu, Jian, Yari, Hooman, Houson, Hailey, Teng, Chengwen, Awasthi, Vibhudutta
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153970/
https://ncbi.nlm.nih.gov/pubmed/30280096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00392
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