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Broad Spectrum and Safety of Oral Treatment with a Promising Nitrosylated Chalcone in Murine Leishmaniasis

The oral efficacy and safety of a leishmanicidal nitrochalcone (CH8) were studied in BALB/c mouse infections with Leishmania amazonensis and Leishmania infantum. Although 10-fold-higher doses of CH8 were needed to produce the same antiparasitic effect as that seen with the reference drug miltefosine...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Antimicrob Agents Chemother
Κύριοι συγγραφείς: Sousa-Batista, Ariane J., Escrivani-Oliveira, Douglas, Falcão, Camila Alves Bandeira, Philipon, Cintia Iana Monteiro da Silva, Rossi-Bergmann, Bartira
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153786/
https://ncbi.nlm.nih.gov/pubmed/30012761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00792-18
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