GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation

Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, the molecular events that predispose WAT to hypertrophy are poorly defined. Here, we demonstrate that adipocyte hypertrophy is triggered by loss of the cor...

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Vydáno v:Cell Rep
Hlavní autoři: Drareni, Karima, Ballaire, Raphaëlle, Barilla, Serena, Mathew, Mano J., Toubal, Amine, Fan, Rongrong, Liang, Ning, Chollet, Catherine, Huang, Zhiqiang, Kondili, Maria, Foufelle, Fabienne, Soprani, Antoine, Roussel, Ronan, Gautier, Jean-François, Alzaid, Fawaz, Treuter, Eckardt, Venteclef, Nicolas
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153369/
https://ncbi.nlm.nih.gov/pubmed/30208320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.032
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