Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy

Vanishing white matter (VWM) disease is an autosomal genetic leukodystrophy caused by mutations in subunits of eukaryotic translation initiation factor 2B (eIF2B). The clinical symptoms exhibit progressive loss of white matter in both hemispheres of the brain, accompanied by motor functions deterior...

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Dettagli Bibliografici
Pubblicato in:Front Mol Neurosci
Autori principali: Atzmon, Andrea, Herrero, Melisa, Sharet-Eshed, Reut, Gilad, Yocheved, Senderowitz, Hanoch, Elroy-Stein, Orna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153319/
https://ncbi.nlm.nih.gov/pubmed/30279648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00336
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